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A historical analysis of herpes simplex virus promoter activation in vivo reveals distinct populations of latently infected neurones

13 Nov 2008

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) has the capacity to establish a life-long latent infection in sensory neurones and also to periodically reactivate from these cells. Since mutant viruses defective for immediate-early (IE) expression retain the capacity for latency establishment it is widely assumed that latency is the consequence of a block in IE gene expression. However, it is not clear whether viral gene...

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PMID: 19008381
DOI: 10.1099/vir.0.2008/005066-0

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