Article
Allelic imbalance within the E-cadherin gene is an infrequent event in prostate carcinogenesis.
Genes, chromosomes & cancer - 1 Jan 2000
Murant S J, Rolley N, Phillips S M, Stower M, Maitland N J
Abstract excerpt
By exploiting two single nucleotide polymorphisms (SNPs) located within the E-cadherin gene, at 16q22, we have determined the frequency of allelic imbalance at this proposed tumor suppressor locus in a series of human prostatic carcinoma DNA samples. Whereas results with seven highly polymorphic microsatellite markers flanking the E-cadherin locus confirmed the existence of three separate loci on chromosome 16,...
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