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Article

Antisense inhibition of amoebapore expression in<i>Entamoeba histolytica</i>causes a decrease in amoebic virulence

1 Nov 1999

Abstract excerpt

Amoebapores have been proposed to be a major pathogenicity factor of the protozoan parasite Entamoeba histolytica, which is responsible for the killing of target cells. These 77-residue peptides are structural and functional analogues of NK-lysin and granulysin of porcine and human cytotoxic lymphocytes. Inhibition of amoebapore gene expression in amoebae was obtained following transfection with a hybrid plasmid...

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PMID: 10564488
DOI: 10.1046/j.1365-2958.1999.01607.x

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