Article
Ancient Weapons for Attack and Defense: the Pore‐forming Polypeptides of Pathogenic Enteric and Free‐living Amoeboid Protozoa<sup>1</sup>
1 Sept 2004
Abstract excerpt
Pore-forming polypeptides have been purified from several amoeboid protozoans that are well-known human pathogens. Obligate enteric parasites, such as Entamoeba histolytica, and free-living but potentially highly pathogenic species, such as Naegleria fowleri, contain these cytolytic molecules inside cytoplasmic granules. Comprehensive functional and structural studies have been conducted that include isolation of...
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