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Article

The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz.

Nature - 6 Feb 1997

Yu Y, Li W, Su K, Yussa M, Han W, Perrimon N, Pick L

Abstract excerpt

Homeobox genes specify cell fate and positional identity in embryos throughout the animal kingdom. Paradoxically, although each has a specific function in vivo, the in vitro DNA-binding specificities of homeodomain proteins are overlapping and relatively weak. A current model is that homeodomain proteins interact with cofactors that increase specificity in vivo. Here we use a native binding site for the...

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PMID: 9020364
DOI: 10.1038/385552a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz.PMID 9020364Read ↗

The nuclear receptor homologue Ftz-F1 and the homeodomain protein Ftz are mutually dependent cofactors.Semantic proximity Read ↗

The nuclear receptor Ftz-F1 and homeodomain protein Ftz interact through evolutionarily conserved protein domains.Semantic proximity Read ↗

Variation and constraint in Hox gene evolution.Semantic proximity Read ↗

Patterning of the Drosophila embryo by a homeodomain-deleted Ftz polypeptide.Semantic proximity Read ↗

Functional conservation of Drosophila FTZ-F1 and its mammalian homologs suggests ligand-independent regulation of NR5A family transcriptional activity.Semantic proximity Read ↗

Inserting the Ftz homeodomain into engrailed creates a dominant transcriptional repressor that specifically turns off Ftz target genes in vivo.Semantic proximity Read ↗

Kinetic analysis of segmentation gene interactions in Drosophila embryos.Semantic proximity Read ↗

Low-level ectopic expression of Fushi tarazu in Drosophila melanogaster results in ftz(Ual/Rpl)-like phenotypes and rescues ftz phenotypes.Semantic proximity Read ↗

Genetic characterization of the homeodomain-independent activity of the Drosophila fushi tarazu gene product.Semantic proximity Read ↗

Pair-rule expression of the Drosophila fushi tarazu gene: a nuclear receptor response element mediates the opposing regulatory effects of runt and hairy.Semantic proximity Read ↗

Multiprotein bridging factor 1 (MBF1) is an evolutionarily conserved transcriptional coactivator that connects a regulatory factor and TATA element-binding protein.Semantic proximity Read ↗

Suboptimal Intermediates Underlie Evolution of the Bicoid Homeodomain.Semantic proximity Read ↗

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