Article
Frequent allelic imbalance but infrequent microsatellite instability in gastric lymphoma.
Leukemia - 1 Nov 1999
Hoeve M A, Ferreira Mota S C, Schuuring E, de Leeuw W J, Chott A, Meijerink J P, Kluin P M, van Krieken J H
Abstract excerpt
Specific defects in DNA repair pathways are reflected by DNA microsatellite instability (MSI) and play an important role in carcinogenesis. Reported frequencies in gastric non-Hodgkin's lymphomas (NHL) vary from 14% to as high as 90%. Another form of genetic instability in tumours is allelic imbalance (AI) due to loss or gain of genetic material at a specific chromosomal region. This might point to the presence...
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