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Article

Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidation.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity - 1 Oct 1999

Astrup A, Toubro S, Dalgaard L T, Urhammer S A, Sorensen T I, Pedersen O

Abstract excerpt

OBJECTIVE: The gene that codes for a novel uncoupling protein, UCP2, has been linked to obesity in animal models. Markers encompassing the UCP2 locus have been linked to energy expenditure in humans. We studied the role of a common amino acid substitution, replacing an alanine (A) with a valine (V) at codon 55, of the coding region of the UCP2 gene for 24-h energy expenditure and respiratory quotient (RQ) in...

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Source

Identifiers

PMID: 10557023
DOI: 10.1038/sj.ijo.0801040

Genes

UCP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidation.PMID 10557023Read ↗

The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency.Semantic proximity Read ↗

Impact of UCP2 polymorphism on long-term exercise-mediated changes in adipocytokines and markers of metabolic syndrome.Semantic proximity Read ↗

The uncoupling protein 2 Ala55Val polymorphism is associated with diabetes mellitus: the CARDIA study.Semantic proximity Read ↗

The role of uncoupling protein 2 and 3 genes polymorphism and energy expenditure in obese Indonesian children.Semantic proximity Read ↗

Genetic variation in UCP2 (uncoupling protein-2) is associated with energy metabolism in Pima Indians.Semantic proximity Read ↗

No relationship between identified variants in the uncoupling protein 2 gene and energy expenditure.Semantic proximity Read ↗

Lack of association between the uncoupling protein-2 Ala55Val gene polymorphism and phenotypic features of the Metabolic Syndrome.Semantic proximity Read ↗

Interactions between uncoupling protein 2 gene polymorphisms, obesity and alcohol intake on liver function: a large meta-analysed population-based study.Semantic proximity Read ↗

Uncoupling protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucose.Semantic proximity Read ↗

The Ala/Val Polymorphism of the UCP2 Gene Is Reciprocally Associated with Aerobic and Anaerobic Performance in AthletesSemantic proximity Read ↗

Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding.Semantic proximity Read ↗

Genetic influences on human energy expenditure and substrate utilization.Semantic proximity Read ↗

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