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Article

2-COP, a Novel Imprinted Gene on Chromosome 7q32, Defines a New Imprinting Cluster in the Human Genome

1 Dec 1999

Abstract excerpt

We describe a novel imprinted gene, gamma 2-COP (nonclathrincoatprotein), identified in a search for expressed sequences in human chromosome 7q32 where the paternally expressed MEST gene is located. gamma 2-COP contains 24 exons and spans >50 kb of genomic DNA. Like MEST, gamma 2-COP is ubiquitously transcribed in fetal and adult tissues. In fetal tissues, including skeletal muscle, skin, kidney, adrenal,...

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Share to Epigenetics and DNA Methylation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10556286
DOI: 10.1093/hmg/8.13.2387

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2-COP, a Novel Imprinted Gene on Chromosome 7q32, Defines a New Imprinting Cluster in the Human GenomePMID 10556286Read ↗

The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome.Semantic proximity Read ↗

The gene TSGA14, adjacent to the imprinted gene MEST, escapes genomic imprinting.Semantic proximity Read ↗

Imprinting analysis of 10 genes and/or transcripts in a 1.5-Mb MEST-flanking region at human chromosome 7q32.Semantic proximity Read ↗

Tissue-specific alternative polyadenylation at the imprinted gene Mest regulates allelic usage at Copg2.Semantic proximity Read ↗

Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32Semantic proximity Read ↗

The novel imprinted carboxypeptidase A4 gene ( CPA4) in the 7q32 imprinting domain.Semantic proximity Read ↗

The GNAS complex locus and human diseases associated with loss-of-function mutations or epimutations within this imprinted gene.Semantic proximity Read ↗

Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses.Semantic proximity Read ↗

The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues.Semantic proximity Read ↗

Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region.Semantic proximity Read ↗

Methylation and expression analyses of the 7q autism susceptibility locus genes MEST , COPG2, and TSGA14 in human and anthropoid primate cortices.Semantic proximity Read ↗

DDC and COBL, flanking the imprinted GRB10 gene on 7p12, are biallelically expressed.Semantic proximity Read ↗

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