Article
The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome.
Journal of medical genetics - 1 Apr 2003
Bentley L, Nakabayashi K, Monk D, Beechey C, Peters J, Birjandi Z, Khayat F E, Patel M, Preece M A, Stanier P, Scherer S W, Moore G E
Abstract excerpt
Imprinted gene(s) on human chromosome 7q32-qter have been postulated to be involved in intrauterine growth restriction associated with Silver-Russell syndrome (SRS) as 7-10% of patients have mUPD(7). Three imprinted genes, MEST, MESTIT1, and COPG2IT1 on chromosome 7q32, are unlikely to cause SRS since epigenetic and sequence mutation analyses have not shown any changes. One hundred kilobases proximal to MEST lies...
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