Article
Methylation and expression analyses of the 7q autism susceptibility locus genes MEST , COPG2, and TSGA14 in human and anthropoid primate cortices.
Cytogenetic and genome research - 1 Jan 2012
Schneider E, Mayer S, El Hajj N, Jensen L R, Kuss A W, Zischler H, Kondova I, Bontrop R E, Navarro B, Fuchs E, Zechner U, Haaf T
Abstract excerpt
The autism susceptibility locus on human chromosome 7q32 contains the maternally imprinted MEST and the non-imprinted COPG2 and TSGA14 genes. Autism is a disorder of the 'social brain' that has been proposed to be due to an overbalance of paternally expressed genes. To study regulation of the 7q32 locus during anthropoid primate evolution, we analyzed the methylation and expression patterns of MEST, COPG2, and...
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