Article
Interaction between calcium-activated chloride channels and the cystic fibrosis transmembrane conductance regulator.
Pflugers Archiv : European journal of physiology - 1 Oct 1999
Wei L, Vankeerberghen A, Cuppens H, Eggermont J, Cassiman J J, Droogmans G, Nilius B
Abstract excerpt
We investigated interactions between cystic fibrosis conductance regulator (CFTR) and endogenous Ca2+-activated Cl- channels (CaCC) in bovine pulmonary artery endothelium (CPAE). CPAE cells, which do not express CFTR, were transiently transfected with wild-type (WT) CFTR and the deletion mutant deltaF508 CFTR. Currents through CaCC were significantly reduced after expression of WT CFTR. This inhibition was...
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