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Article

Genesis of variant Philadelphia chromosome translocations in chronic myelocytic leukemia.

Cancer genetics and cytogenetics - 1 Nov 2003

Naumann Sabine, Decker Hans-Jochen

Abstract excerpt

The Philadelphia (Ph) chromosome is found in more than 90% of chronic myelocytic leukemia (CML) patients. In most cases, it results from the reciprocal t(9;22)(q34;q11), with the ABL proto-oncogene from 9q34 fused to the breakpoint cluster region (BCR) locus on 22q11. In 5%-10% of patients with CML, the Ph chromosome originates from variant translocations, involving various breakpoints in addition to 9q34 and...

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PMID: 14580766
DOI: 10.1016/s0165-4608(03)00128-6

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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