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Article

Identification and specificities of N-terminal acetyltransferases from Saccharomyces cerevisiae.

The EMBO journal - 1 Nov 1999

Polevoda B, Norbeck J, Takakura H, Blomberg A, Sherman F

Abstract excerpt

N-terminal acetylation can occur cotranslationally on the initiator methionine residue or on the penultimate residue if the methionine is cleaved. We investigated the three N-terminal acetyltransferases (NATs), Ard1p/Nat1p, Nat3p and Mak3p. Ard1p and Mak3p are significantly related to each other by amino acid sequence, as is Nat3p, which was uncovered in this study using programming alignment procedures. Mutants...

Topics

Acetylation
Acetyltransferases
Amino Acid Sequence
Base Sequence
Cytochrome c Group
Cytochromes c
Electrophoresis, Gel, Two-Dimensional
Fungal Proteins
Molecular Sequence Data
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Sequence Alignment

Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 10545125
DOI: 10.1093/emboj/18.21.6155
PMCID: PMC1171679

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