Nα-terminal Acetylation of Eukaryotic Proteins

Abstract excerpt

NH2-terminal, Nα-terminal N-terminal acetyltransferase The two cotranslational processes, cleavage of N-terminal methionine residues and N-terminal1 acetylation, are by far the most common modifications, occurring on the vast majority of eukaryotic proteins. Studies with the yeast Saccharomyces cerevisiae revealed three N-terminal acetyltransferases, NatA, NatB, and NatC, that acted on groups of substrates, each...

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