Article
Common mutation of plasminogen detected in three Asian populations by an amplification refractory mutation system and rapid automated capillary electrophoresis.
Thrombosis and haemostasis - 1 Oct 1999
Ooe A, Kida M, Yamazaki T, Park S C, Hamaguchi H, Girolami A, Ichinose A
Abstract excerpt
Congenital deficiency and dysfunction of plasminogen (PLG) are associated with a mild thrombotic tendency. To facilitate the genetic diagnosis of dysPLGemia, we combined an amplification refractory mutation system and rapid automated capillary electrophoresis. Two different fluorescence-labeled PLG-specific primers for exon XV were designed so that each DNA amplified by PCR showed fluorescence of a different...
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