Article
Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1991
Ichinose A, Espling E S, Takamatsu J, Saito H, Shinmyozu K, Maruyama I, Petersen T E, Davie E W
Abstract excerpt
The gene coding for plasminogen has been compared with several abnormal genes from Japanese patients by the polymerase chain reaction and DNA sequence analysis. Two types of abnormal genes coding for plasminogen were identified in these patients. In the type I mutation, a guanosine in GCT coding for Ala-601 near the active-site histidine was replaced by an adenosine resulting in ACT coding for threonine. This...
Topics
- Base Sequence
- DNA
- Exons
- Genes
- Humans
- Japan
- Leukocytes
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Plasminogen