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Article

Mutations and loss of expression of a mismatch repair gene, hMLH1, in leukemia and lymphoma cell lines.

Blood - 1 Mar 1997

Hangaishi A, Ogawa S, Mitani K, Hosoya N, Chiba S, Yazaki Y, Hirai H

Abstract excerpt

Defects in genes involved in DNA mismatch repair have been detected in both hereditary and sporadic tumors of colon, endometrium, and ovary and suggested to be associated with tumorigenesis. To investigate disruptions of the mismatch repair system in hematological malignancies, we examined altera...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9057658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9057658-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Mutations and loss of expression of a mismatch repair gene, hMLH1, in leukemia and lymphoma cell lines.PMID 9057658Read ↗

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Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1Semantic proximity Read ↗

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.Semantic proximity Read ↗

Mechanisms of inactivation of mismatch repair genes in human colorectal cancer cell lines: The predominant role of hMLH1Semantic proximity Read ↗

High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas.Semantic proximity Read ↗

Human mismatch-repair protein MutL homologue 1 (MLH1) interacts with Escherichia coli MutL and MutS in vivo and in vitro: a simple genetic system to assay MLH1 function.Semantic proximity Read ↗

Somatic mutations of a human mismatch repair gene, hMLH1, in tumors from patients with multiple primary cancers.Semantic proximity Read ↗

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