Article
Dopamine D2 receptor gene polymorphism and the risk of levodopa-induced dyskinesias in PD.
Neurology - 22 Oct 1999
Oliveri R L, Annesi G, Zappia M, Civitelli D, Montesanti R, Branca D, Nicoletti G, Spadafora P, Pasqua A A, Cittadella R, Andreoli V, Gambardella A, Aguglia U, Quattrone A
Abstract excerpt
OBJECTIVE: To investigate whether polymorphisms in the genes for dopamine receptors D1 and D2 are associated with the risk of developing peak-dose dyskinesias in PD. BACKGROUND: Peak-dose dyskinesias are the most common side effects of levodopa therapy for PD. The identified predictors may only partially account for the risk of developing peak-dose dyskinesias because a substantial proportion of patients never...
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