Article
Polymorphisms of dopamine receptor and transporter genes and Parkinson's disease.
Journal of neural transmission. Parkinson's disease and dementia section - 1 Jan 1995
Higuchi S, Muramatsu T, Arai H, Hayashida M, Sasaki H, Trojanowski J Q
Abstract excerpt
Disturbances of the dopamine system are involved in the pathogenesis of idiopathic Parkinson's disease (PD). Although genetic factors may play a role in the etiology of PD, there is little direct evidence implicating a specific gene. We conducted a study to test the hypothesis that allelic variations of the dopamine receptors (D2, D3, D4) and the dopamine transporter (DAT) contribute to the susceptibility to PD....
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