Article
p53 gene mutations and overexpression of p53 product in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction.
Journal of hepato-biliary-pancreatic surgery - 1 Jan 1999
Matsubara T, Funabiki T, Jinno O, Sakurai Y, Hasegawa S, Imazu H, Ochiai M
Abstract excerpt
To investigate the molecular mechanisms of the high incidence of carcinogenesis in the biliary epithelium of patients with pancreaticobiliary maljunction, we examined p53 gene mutations, loss of heterozygosity of p53, and overexpression of p53 gene product in the cancerous and noncancerous biliary epithelium of 27 patients with pancreaticobiliary maljunction. Mutations of the p53 gene were examined by polymerase...
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