Article
Clinical and genetic analysis of noncancerous and cancerous biliary epithelium in patients with pancreaticobiliary maljunction.
World journal of surgery - 1 Jan 2002
Nagai Moritaka, Watanabe Masatoshi, Iwase Teruhiko, Yamao Kenji, Isaji Shuji
Abstract excerpt
We analyzed clinical features and genetic alterations in the noncancerous and cancerous biliary lesions obtained from pancreaticobiliary maljunction (PBM) patients. Gallbladder (GB) and bile duct (BD) lesions were obtained surgically from 36 patients with PBM, and polymerase chain reaction (PCR) methods were used to examine for mutations of the K-ras gene and the p53 gene and for microsatellite instability (MSI)....
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