Article
The GPIIIa Pl(A) polymorphism in the progression of abdominal aortic atherosclerosis.
Atherosclerosis - 1 Nov 1999
Mikkelsson J, Perola M, Kauppila L I, Laippala P, Savolainen V, Pajarinen J, Penttilä A, Karhunen P J
Abstract excerpt
Glycoprotein IIIa is expressed in platelets as part of the fibrinogen receptor and also in vascular endothelium where it mediates smooth muscle cell proliferation. The association between the glycoprotein GPIIIa Pl(A) polymorphism and the stage of atherosclerosis in the abdominal aorta was studied in a prospective autopsy study series of 300 middle-aged men (33-69 years). The Pl(A) genotype was determined by...
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