Article
Glycoprotein IIIa Pl(A) polymorphism associates with progression of coronary artery disease and with myocardial infarction in an autopsy series of middle-aged men who died suddenly.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 1999
Mikkelsson J, Perola M, Laippala P, Savolainen V, Pajarinen J, Lalu K, Penttilä A, Karhunen P J
Abstract excerpt
Glycoprotein IIIa (GPIIIa) has a key role in the aggregation of thrombocytes, and it also mediates intimal hyperplasia after endothelial injuries; the possible association of the Pl(A1/A2) polymorphism of the gene for GPIIIa with coronary thrombosis and with the progression of coronary artery disease (CAD) is still to be confirmed. Therefore, the association of the Pl(A) polymorphism with the development of...
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