Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic potential of EAG K(+) channels.

The EMBO journal - 15 Oct 1999

Pardo L A, del Camino D, Sánchez A, Alves F, Brüggemann A, Beckh S, Stühmer W

Abstract excerpt

We have investigated the possible implication of the cell cycle-regulated K(+) channel ether à go-go (EAG) in cell proliferation and transformation. We show that transfection of EAG into mammalian cells confers a transformed phenotype. In addition, human EAG mRNA is detected in several somatic cancer cell lines, despite being preferentially expressed in brain among normal tissues. Inhibition of EAG expression in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Ether-A-Go-Go Potassium Channels
Share to In Situ Hybridization, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, SCID

Share to Neoplasms, Experimental

Share to Oligodeoxyribonucleotides, Antisense

Share to Potassium Channels

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 10523298
DOI: 10.1093/emboj/18.20.5540
PMCID: PMC1171622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic potential of EAG K(+) channels.PMID 10523298Read ↗

Ether a go-go Potassium Channels as Human Cervical Cancer MarkersSemantic proximity Read ↗

Potassium channels as tumour markersSemantic proximity Read ↗

K+ channels and cell cycle progression in tumor cellsSemantic proximity Read ↗

HERG channel and cancer: A mechanistic review of carcinogenic processes and therapeutic potential.Semantic proximity Read ↗

Frequent aberrant expression of the human ether à go-go (hEAG1) potassium channel in head and neck cancer: pathobiological mechanisms and clinical implicationsSemantic proximity Read ↗

Cell Cycle-dependent Expression of HERG1 and HERG1B Isoforms in Tumor CellsSemantic proximity Read ↗

Identification of a Posttranslational Mechanism for the Regulation of hERG1 K+ Channel Expression and hERG1 Current Density in Tumor CellsSemantic proximity Read ↗

Neuro-bioenergetic concepts in cancer prevention and treatment.Semantic proximity Read ↗

Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95).Semantic proximity Read ↗

Targeting Ion Channels in Cancer: A Novel Frontier in Antineoplastic TherapySemantic proximity Read ↗

Selective expression of HERG and Kv2 channels influences proliferation of uterine cancer cellsSemantic proximity Read ↗

Gap junctions and cancer: communicating for 50 years.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.