Article
Hemoglobin British Columbia (alpha2beta2 101(G3)Glu replaced by Lys). A new variant with high oxygen affinity.
Hemoglobin - 1 Jan 2000
Jones R T, Brimhall B, Gray G
Abstract excerpt
Hemoglobin British Columbia was found in an East Indian living in Vancouver, British Columbia, Canada. Its structure was demonstrated to be alpha2beta2 101(G3)Glu replaced by Lys. It has a significant increase in oxygen affinity, decrease in heme-heme interaction, but normal Bohr effect. Unlike Hb Rush (beta101 Glu replaced by Glu), it is as stable as Hb A to heat and alcohol denaturation. By both cellulose...
Topics
- Adult
- British Columbia
- Chromatography, Ion Exchange
- Electrophoresis, Cellulose Acetate
- Genetic Variation
- Glutamine
- Hemoglobins, Abnormal
- Humans
- Lysine
- Male
- Oxyhemoglobins