Article
Transferrin receptor 2 is frequently expressed in human cancer cell lines.
Blood cells, molecules & diseases - 1 Jan 2000
Calzolari Alessia, Oliviero Isabella, Deaglio Silvia, Mariani Gualtiero, Biffoni Mauro, Sposi Nadia Maria, Malavasi Fabio, Peschle Cesare, Testa Ugo
Abstract excerpt
Different proteins ensure the fine control of iron metabolism at the level of various tissues. Among these proteins, it was discovered a second transferrin receptor (TfR2), that seems to play a key role in the regulation of iron homeostasis. Its mutations are responsible for type 3 hemochromatosis (Type 3 HH). Although TfR2 expression in normal tissues was restricted at the level of liver and intestine, we...
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