Article
Hepatitis B virus infection and hepatocellular carcinoma: molecular genetics and clinical perspectives.
Seminars in liver disease - 1 Jan 1999
Chen P J, Chen D S
Abstract excerpt
Chronic hepatitis B progresses across a spectrum of asymptomatic carriers, active hepatitis, and liver cirrhosis. With more advanced disease stage, the risk for developing hepatocellular carcinoma (HCC) becomes higher. Recent studies suggest that this progressive risk may reflect an accumulation of multistage genetic mutations in the chromosomes of affected hepatocytes. Mutations of the known candidate genes such...
Topics
- Animals
- Carcinoma, Hepatocellular
- Genes, Tumor Suppressor
- Hepatitis B, Chronic
- Humans
- Liver Neoplasms
- Loss of Heterozygosity
- Mutation
- Proto-Oncogenes
- Risk Factors