The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.

doi:10.1002/path.4434

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Article

The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets.

The Journal of pathology - 1 Jan 2015

Ringelhan Marc, O'Connor Tracy, Protzer Ulrike, Heikenwalder Mathias

Abstract excerpt

Chronic hepatitis B virus (HBV) infection remains the number one risk factor for hepatocellular carcinoma (HCC), accounting for more than 600 000 deaths/year. Despite highly effective antiviral treatment options, chronic hepatitis B (CHB), subsequent end-stage liver disease and HCC development remain a major challenge worldwide. In CHB, liver damage is mainly caused by the influx of immune cells and destruction...

Topics

Animals
Antiviral Agents
Biomarkers, Tumor
Carcinoma, Hepatocellular
DNA, Viral
Genotype
Hepatitis B virus
Hepatitis B, Chronic
Host-Pathogen Interactions
Humans
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Predictive Value of Tests

Risk Factors

Viral Load

Viral Proteins

Virulence

Virus Integration

Source

Open in PubMed

Identifiers

PMID: 25196558
DOI: 10.1002/path.4434

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25196558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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