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Genetic Alterations and Oncogenic Pathways in Hepatocellular Carcinoma

1 Jun 2002

Abstract excerpt

Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. Chronic infections with the hepatitis B virus (HBV) and the hepatitis C virus (HCV) have been implicated in about 80% of cases worldwide, and other known environmental risk factors, including alcohol abuse and dietary intake of aflatoxin B1, might synergize with viral...

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PMID: 12095925
DOI: 10.1111/j.1749-6632.2002.tb04091.x

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