Wnt Pathway, Angiogenetic and Hormonal Markers in Sporadic and Familial Adenomatous Polyposis-associated Juvenile Nasopharyngeal Angiofibromas (JNA)

Abstract excerpt

Juvenile nasopharyngeal angiofibroma (JNA) is a rare, invasive, and locally destructive tumor of the nasopharynx. The Wnt pathway, angiogenetic and hormonal factors are involved in the pathophysiology of JNA; it can result in an extracolonic manifestation of familial adenomatous polyposis (FAP) or in a sporadic tumor. All patients who underwent resection of JNA between 1991 and 2006 at the University of Modena...