Article
Molecular pathogenesis of juvenile nasopharyngeal angiofibroma in brazilian patients.
Pediatric hematology and oncology - 1 Oct 2013
Maniglia Maurício Pereira, Ribeiro Maria Estela Bellini, Costa Nauyla Miranda da, Jacomini Marta Lúcia Gabriel, Carvalho Thiago Bittencourt Ottoni de, Molina Fernando Drimel, Piatto Vânia Belintani, Maniglia José Victor
Abstract excerpt
Juvenile nasopharyngeal angiofibroma (JNA) is a vascular tumor of the nasopharynx that accounts for 0.5% of all cancers of the head and neck. It primarily affects males aged 14-25 years. Of the many genes that mediate the development of JNA, GSTM1 has been most frequently associated with this vascular tumor. The loss of expression of GSTM1 (null genotype) is linked to the development of these tumors. The aim of...
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