Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of Measles Virus Nucleocapsid Protein in Osteoclasts Induces Paget's Disease-Like Bone Lesions in Mice

1 Mar 2006

Abstract excerpt

UNLABELLED: We targeted the MVNP gene to the OCL lineage in transgenic mice. These mice developed abnormal OCLs and bone lesions similar to those found in Paget's patients. These results show that persistent expression of MVNP in OCLs can induce pagetic-like bone lesions in vivo. INTRODUCTION: Paget's disease (PD) of bone is the second most common bone disease. Both genetic and viral factors have been implicated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Joint Diseases
Share to Bone health and treatments
Share to Bone Metabolism and Diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16491293
DOI: 10.1359/jbmr.051108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of Measles Virus Nucleocapsid Protein in Osteoclasts Induces Paget's Disease-Like Bone Lesions in MicePMID 16491293Read ↗

Osteoclasts expressing the measles virus nucleocapsid gene display a pagetic phenotype.Semantic proximity Read ↗

Osteoclasts formed by measles virus-infected osteoclast precursors from hCD46 transgenic mice express characteristics of pagetic osteoclasts.Semantic proximity Read ↗

Pathobiology of Paget's Disease of BoneSemantic proximity Read ↗

Increased IL-6 expression in osteoclasts is necessary but not sufficient for the development of Paget's disease of bone.Semantic proximity Read ↗

Measles virus nucleocapsid protein increases osteoblast differentiation in Paget’s diseaseSemantic proximity Read ↗

Insights into the pathogenesis of Paget's diseaseSemantic proximity Read ↗

Bone marrow mononuclear cells from patients with Paget's disease contain measles virus nucleocapsid messenger ribonucleic acid that has mutations in a specific region of the sequence.Semantic proximity Read ↗

Contributions of the measles virus nucleocapsid gene and the SQSTM1/p62(P392L) mutation to Paget's disease.Semantic proximity Read ↗

Paget's disease of bone.Semantic proximity Read ↗

A putative role for c-Fos in the pathophysiology of Paget's disease.Semantic proximity Read ↗

Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease.Semantic proximity Read ↗

Differential Gene Expression in Cultured Osteoblasts and Bone Marrow Stromal Cells From Patients With Paget's Disease of BoneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.