Article
Regulation of acidification and apoptosis by SHP-1 and Bcl-2.
The Journal of biological chemistry - 8 Oct 1999
Thangaraju M, Sharma K, Leber B, Andrews D W, Shen S H, Srikant C B
Abstract excerpt
Recruitment of the SH2 domain containing cytoplasmic protein-tyrosine phosphatase SHP-1 to the membrane by somatostatin (SST) is an early event in its antiproliferative signaling that induces intracellular acidification-dependent apoptosis in breast cancer cells. Fas ligation also induces acidification-dependent apoptosis in a manner requiring the presence of SHP-1 at the membrane. Moreover, we have recently...
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