Article
Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA.
Lancet (London, England) - 18 Sept 1999
Makridakis N M, Ross R K, Pike M C, Crocitto L E, Kolonel L N, Pearce C L, Henderson B E, Reichardt J K
Abstract excerpt
BACKGROUND: Prostate cancer is a very common disease in more-developed countries, but its cause is largely unknown. It is an androgen-dependent cancer, and androgens have been proposed as having a substantial role in predisposition to the disease. Thus, variations in androgen metabolism genes may affect risk of this disease. METHODS: We screened 216 African-American and 172 Hispanic men with prostate cancer, and...
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