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Article

Stimulation of spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mutant mice by gonadotropin-releasing hormone antagonist treatment.

Endocrinology - 1 Oct 1999

Matsumiya K, Meistrich M L, Shetty G, Dohmae K, Tohda A, Okuyama A, Nishimune Y

Abstract excerpt

Male juvenile spermatogonial depletion (jsd) mutant mice are sterile because of spermatogenic failure and so may provide a model for genetically caused human male infertility. To test the effects of testosterone suppression therapy on spermatogenesis in jsd/jsd mice, we treated them with Nal-Glu, a GnRH antagonist. Treatment with Nal-Glu at 2500 microg/kg/day was started at 5.5 or 8 weeks of age and continued for...

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PMID: 10499552
DOI: 10.1210/endo.140.10.7026

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