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Article

Neuregulins are essential for spermatogonial proliferation and meiotic initiation in neonatal mouse testis.

Development (Cambridge, England) - 1 Aug 2011

Zhang JiDong, Eto Ko, Honmyou Asuka, Nakao Kazuki, Kiyonari Hiroshi, Abé Shin-ichi

Abstract excerpt

The transition from mitosis to meiosis is unique to germ cells. In murine embryonic ovaries and juvenile testes, retinoic acid (RA) induces meiosis via the stimulated by retinoic acid gene 8 (Stra8), but its molecular pathway requires elucidation. We present genetic evidence in vivo and in vitro that neuregulins (NRGs) are essential for the proliferation of spermatogonia and the initiation of meiosis. Tamoxifen...

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Source

Identifiers

PMID: 21715427
DOI: 10.1242/dev.062380

Genes

NRG1
NRG3
STRA8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Neuregulins are essential for spermatogonial proliferation and meiotic initiation in neonatal mouse testis.PMID 21715427Read ↗

Recent Update on Retinoic Acid-Driven Initiation of Spermatogonial DifferentiationSemantic proximity Read ↗

Periodic retinoic acid–STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesisSemantic proximity Read ↗

The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells.Semantic proximity Read ↗

Mammalian gonocyte and spermatogonia differentiation: recent advances and remaining challengesSemantic proximity Read ↗

Roles ofStra8andTcerg1lin retinoic acid induced spermatogonial differentiation in mouseSemantic proximity Read ↗

Retinoic Acid Availability Drives the Asynchronous Initiation of Spermatogonial Differentiation in the Mouse1Semantic proximity Read ↗

The Role of Retinoic Acid (RA) in Spermatogonial Differentiation1Semantic proximity Read ↗

Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesisSemantic proximity Read ↗

Cycles, waves, and pulses: Retinoic acid and the organization of spermatogenesisSemantic proximity Read ↗

Stimulated by retinoic acid gene 8 (Stra8) plays important roles in many stages of spermatogenesisSemantic proximity Read ↗

Retinoic acid prevents germ cell mitotic arrest in mouse fetal testesSemantic proximity Read ↗

<i>Stra8</i> and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in miceSemantic proximity Read ↗

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