Article
[Recent progress of pathogenesis and treatment in alpha 1-antitrypsin deficiency].
Nihon rinsho. Japanese journal of clinical medicine - 1 Sept 1999
Ozaki I, Zern M A
Abstract excerpt
alpha 1-Antitrypsin (alpha 1-AT) deficiency, one of the most common hereditary disorders that mainly affects the lung and liver in Caucasian people, is caused by mutations of alpha 1-AT gene. Decrease of serum alpha 1-AT concentration is directly responsible for lung emphysema, replacement of plasma-derived alpha 1-AT concentrate is administered to patients of alpha 1-AT deficiency with lung emphysema, and lung...
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