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Article

Alpha-1 antitrypsin deficiency: pathogenesis, clinical presentation, diagnosis, and treatment.

The American journal of medicine - 1 Jan 2008

Köhnlein Thomas, Welte Tobias

Abstract excerpt

Alpha-1 antitrypsin deficiency is an inherited disease affecting the lung and liver. The typical pulmonary manifestation is chronic obstructive pulmonary disease and emphysema. Severe chronic obstructive pulmonary disease may occur in young adulthood, and terminal respiratory insufficiency causes premature death in many patients. In the liver, alpha-1 antitrypsin deficiency may manifest as benign neonatal...

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PMID: 18187064
DOI: 10.1016/j.amjmed.2007.07.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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