Hypothesis: genes which function in a stochastic lineage commitment process are subject to monoallelic expression.

Abstract excerpt

The collection of genes which are now known to be monoallelically expressed in mammals is a diverse set. In the case of the genes which encode transducing receptors, such as immunoglobulins or odoront receptors, monoallelic expression ensures that cell activity is related to encountering a unique ligand. However, some monoallelically expressed genes do not encode receptors, and in these cases the physiological...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Cell Lineage
• Share to Cytokines