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Article

The GTP-binding domain of McrB: more than just a variation on a common theme?

Journal of molecular biology - 24 Sept 1999

Pieper U, Schweitzer T, Groll D H, Gast F U, Pingoud A

Abstract excerpt

The methylation-dependent restriction endonuclease McrBC from Escherichia coli K12 cleaves DNA containing two R(m)C dinucleotides separated by about 40 to 2000 base-pairs. McrBC is unique in that cleavage is totally dependent on GTP hydrolysis. McrB is the GTP binding and hydrolyzing subunit, whereas MrC stimulates its GTP hydrolysis. The C-terminal part of McrB contains the sequences characteristic for...

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Source

Identifiers

PMID: 10497020
DOI: 10.1006/jmbi.1999.3103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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