Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and sequence organization of the mcrBC locus of Escherichia coli K-12.

Journal of bacteriology - 1 Sept 1990

Dila D, Sutherland E, Moran L, Slatko B, Raleigh E A

Abstract excerpt

The mcrB (rglB) locus of Escherichia coli K-12 mediates sequence-specific restriction of cytosine-modified DNA. Genetic and sequence analysis shows that the locus actually comprises two genes, mcrB and mcrC. We show here that in vivo, McrC modifies the specificity of McrB restriction by expanding the range of modified sequences restricted. That is, the sequences sensitive to McrB(+)-dependent restriction can be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Genes, Bacterial

Share to Molecular Sequence Data

Share to Phenotype

Share to Plasmids

Source

Open in PubMed Open full text

Identifiers

PMID: 2203735
DOI: 10.1128/jb.172.9.4888-4900.1990
PMCID: PMC213143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and sequence organization of the mcrBC locus of Escherichia coli K-12.PMID 2203735Read ↗

Characterization of the mcrBC region of Escherichia coli K-12 wild-type and mutant strains.Semantic proximity Read ↗

Nomenclature relating to restriction of modified DNA in Escherichia coli.Semantic proximity Read ↗

The GTP-binding domain of McrB: more than just a variation on a common theme?Semantic proximity Read ↗

A novel activity in Escherichia coli K-12 that directs restriction of DNA modified at CG dinucleotides.Semantic proximity Read ↗

Isolation of temperature-sensitive McrA and McrB mutations and complementation analysis of the McrBC region of Escherichia coli K-12.Semantic proximity Read ↗

Cloning and structural characterization of the mcrA locus of Escherichia coli.Semantic proximity Read ↗

The complete genome sequence of Escherichia coli K-12.Semantic proximity Read ↗

Modified-cytosine restriction-system-induced recombinant cloning artefacts in Escherichia coli.Semantic proximity Read ↗

Transposon-mediated linker insertion scanning mutagenesis of the Escherichia coli McrA endonuclease.Semantic proximity Read ↗

EcoBLMcrX, a classical modification-dependent restriction enzyme in Escherichia coli B: Characterization in vivo and in vitro with a new approach to cleavage site determination.Semantic proximity Read ↗

Sequence divergence of the murB and rrfB genes from Escherichia coli and Salmonella typhimurium.Semantic proximity Read ↗

Genomic sequencing reveals regulatory mutations and recombinational events in the widely used MC4100 lineage of Escherichia coli K-12.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.