Article
No evidence for association of multiple sclerosis with the complement factors C6 and C7.
Journal of neuroimmunology - 1 Sept 1999
Chataway J, Sawcer S, Sherman D, Hobart M, Fernie B, Coraddu F, Feakes R, Broadley S, Gray J, Jones H B, Clayton D, Goodfellow P N, Compston A
Abstract excerpt
Four genome screens in multiple sclerosis have been completed and each has identified evidence for linkage in the pericentromeric region of chromosome 5. This region encodes a number of candidate genes including those for the complement components C6, C7 and C9. We have used a multiplexed oligoligation assay (OLA) to test single nucleotide polymorphisms (SNPs) from the C6 and C7 genes for evidence of association...
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