Article
No evidence of linkage between 7q33-36 locus (OTSC2) and otosclerosis in seven British Caucasian pedigrees.
The Journal of laryngology and otology - 1 Dec 2007
Alzoubi F Q, Ollier W R, Ramsden R T, Saeed S R
Abstract excerpt
BACKGROUND: The aetiology of otosclerosis is complex, and probably involves an interaction between genes and environmental factors. Previous studies have revealed genetic linkage with a number of chromosome regions, including position 7q33-36. AIM: To confirm whether linkage exists between otosclerosis and chromosome region 7q33-36. MATERIALS AND METHODS: Seven multiply affected families were ascertained....
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