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Article

Segregation analysis of idiopathic scoliosis: demonstration of a major gene effect.

American journal of medical genetics - 8 Oct 1999

Axenovich T I, Zaidman A M, Zorkoltseva I V, Tregubova I L, Borodin P M

Abstract excerpt

Segregation analysis using a model with age and gender effects was applied to 101 pedigrees ascertained through a proband with idiopathic scoliosis. The transmission probability model was used to detect major gene effect. When we analyzed the pedigrees where affected status was assigned to persons with a Cobb's angle of more than 5 degrees we did not detect a significant major gene effect. However, when the...

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PMID: 10494097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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