Familial high myopia: evidence of an autosomal dominant mode of inheritance and genetic heterogeneity.

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Article

Familial high myopia: evidence of an autosomal dominant mode of inheritance and genetic heterogeneity.

Annales de genetique - 1 Jan 1999

Naiglin L, Clayton J, Gazagne C, Dallongeville F, Malecaze F, Calvas P

Abstract excerpt

High myopia, defined as a refractive error inferior to -6 diopters, often appears as a familial disease. In order to precise its genetic background, we performed a segregation analysis on 32 French families (320 subjects including 120 individuals with clinical data) containing at least one high myopic person in their genealogy. Under the assumption of a two-alleles single gene model, the autosomal dominant...

Topics

Alleles
Chromosome Segregation
Female
Genes, Dominant
Genetic Heterogeneity
Genetic Linkage
Genotype
Humans
Lod Score
Male
Myopia

Source

Open in PubMed

Identifiers

PMID: 10526656

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