Article
Segregation of structural collagen genes in adolescent idiopathic scoliosis.
Clinical orthopaedics and related research - 1 Jan 1992
Carr A J, Ogilvie D J, Wordsworth B P, Priestly L M, Smith R, Sykes B
Abstract excerpt
The etiology of idiopathic scoliosis remains unknown. The condition results in a characteristic deformity of the spine and surrounding tissues. Both Types I and II collagen are important constituents of the affected tissues, and thus defective collagens are reasonable candidates for the primary abnormality in adolescent idiopathic scoliosis (AIS). Direct analyses of the amount and solubility of collagen have...
Topics
- Adolescent
- Child
- Collagen
- Female
- Genetic Markers
- Humans
- Male
- Pedigree
- Phenotype
- Polymorphism, Restriction Fragment Length
- Restriction Mapping
- Scoliosis