Genetic association of complex traits: using idiopathic scoliosis as an example.

doi:10.1097/BLO.0b013e3180d09dcc

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Article

Genetic association of complex traits: using idiopathic scoliosis as an example.

Clinical orthopaedics and related research - 1 Sept 2007

Cheng Jack C Y, Tang Nelson L S, Yeung Hiu-Yan, Miller Nancy

Abstract excerpt

Although the exact etiology of adolescent idiopathic scoliosis is still undefined, genetic factors play an important role. Some patients have familial genetic disease that appears to have an autosomal dominant pattern. Linkage studies of these families revealed multiple potential genetic loci that may predispose individuals to the condition. Additional genetic analysis is required to identify the...

Topics

Adolescent
DNA Mutational Analysis
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genomics
Humans
Polymorphism, Single Nucleotide
Scoliosis

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Open in PubMed

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PMID: 17534191
DOI: 10.1097/BLO.0b013e3180d09dcc

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