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Article

MG132, a proteasome inhibitor, induces apoptosis in tumor cells

15 May 2012

Abstract excerpt

The balance between cell proliferation and apoptosis is critical for normal development and for the maintenance of homeostasis in adult organisms. Disruption of this balance has been implicated in a large number of disease processes, ranging from autoimmunity and neurodegenerative disorders to cancer. The ubiquitin-proteasome pathway, responsible for mediating the majority of intracellular proteolysis, plays a...

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PMID: 22897979
DOI: 10.1111/j.1743-7563.2012.01535.x

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