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p53-mediated G1 arrest requires the induction of both p21 and Killin in human colon cancer cells

8 Dec 2021

Abstract excerpt

The main biological function of the tumor suppressor p53 is to control cell cycle arrest and apoptosis. Among the p53 target genes, p21 has been identified as a key player in p53-mediated G1 arrest, while Killin, via its high DNA binding affinity, has been implicated in S and G2/M arrest. However, whether Killin is involved in G1 arrest remains unclear. This research aimed to explore the role of Killin in...

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PMID: 34878965
DOI: 10.1080/15384101.2021.2014249

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