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Article

Altered flexibility in the substrate-binding site of related native and engineered high-alkaline Bacillus subtilisins.

Journal of molecular biology - 10 Sept 1999

Mulder F A, Schipper D, Bott R, Boelens R

Abstract excerpt

High-alkaline serine proteases have been successfully applied as protein degrading components of detergent formulations and are subject to extensive protein engineering efforts to improve their stability and performance. Dynamics has been suggested to play an important role in determining enzyme activity and specificity and it is therefore of interest to establish how local changes in internal mobility affect...

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Source

Identifiers

PMID: 10493861
DOI: 10.1006/jmbi.1999.3034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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